Results of contralateral anastomosis of microvascular free flaps in head and neck reconstruction.

OBJECTIVES: Despite various solutions to the issue of ipsilateral vessel-depleted neck in microvascular head and neck reconstruction, concrete data on its safety and implementation are scarce. This paper focuses on the feasibility and success rates of contralateral anastomosis in free flap reconstruction in the head and neck region. METHODS: This single-center retrospective study at a tertiary referral center includes all patients who underwent free flap reconstruction of the head and neck with contralateral anastomosis between January 1st, 2007 and February 28th, 2021. Primary objectives were frequency, success, and flap-associated complication rates. Secondary objectives were recipient vessels and flap type. RESULTS: Of 318 patients who underwent microvascular reconstruction, anastomosis was performed on the contralateral side of the neck in 32 patients (10.0%). Recipient vessels involved mainly the superior thyroid artery (74.2%; n = 23) and the facial vein (51.1%; n = 23). Thirty patients (93.8%) received a radial forearm free flap. Flap-associated complications occurred in 12.5% of included cases (n = 4): one partial flap necrosis (3.1%), one anastomotic insufficiency (3.1%), one venous thrombosis of the microvascular pedicle (3.1%), and one wound dehiscence (3.1%). All of these complications were resolved without complete flap loss. CONCLUSION: This study demonstrates that contralateral anastomosis is a successful and safe option in microvascular head and neck reconstruction, especially using a radial forearm free flap. Thus, anastomosing to the contralateral side of the neck can be advocated as a valuable option in the ipsilateral vessel-depleted neck.

Hazard of CO2 laser-induced airway fire in laryngeal surgery: experimental data of contributing factors.

In carbon dioxide (CO2) laser surgery of the larynx, the potentially dangerous combination of laser-induced heat in an oxygen-enriched atmosphere typically occurs when jet ventilation is used or due to an insufficiently blocked endotracheal tube. Until now, no limitations for safe oxygen concentrations or laser intervals have been established. The aim of this study was to investigate and quantify the factors that may contribute to an airway fire in laryngeal laser surgery. Fat, muscle and cartilage were irradiated with a CO2 laser at 2, 4, 6 and 8 W in five different oxygen concentrations with and without smoke exhaustion. The time to ignition was recorded for each different experimental setup. Fat burnt fastest, followed by cartilage and muscle. The elevation of laser energy or oxygen concentration reduced the time to inflammation of any tissue. The elevation of oxygen by 10 % increases the risk of inflammation more than the elevation of laser power by 2 W. Under smoke exhaustion, inflammation and burning occurred delayed or were even inhibited at lower oxygen concentrations. Lasing in more than 50 % oxygen is comparatively dangerous and can cause airway fire in less than 5 s, especially when laser energies of more than 5 W are applied. In equal or lower than 50 % oxygen, an irradiation interval of 5 s can be considered a comparatively safe time limit to prevent inflammation in laryngeal laser surgery. Smoke exhaustion should always be applied.

Idiopathic sudden hearing loss: contradictory clinical evidence, placebo effects and high spontaneous recovery rate--where do we stand in assessing treatment outcomes?

Idiopathic sudden hearing loss (ISHL) has an estimated incidence of 10-20/100,000 per year, impairing not only patients' hearing but also their ability to interact socially and their quality of life. Confronted with patients who demand successful treatment, physicians need to judge potential treatment options with regard to their reported efficiency, as well as their suitability for the individual patient. The dilemma of assessing treatment outcomes and options in ISHL will be discussed regarding a lack of knowledge of the disease's etiology, contradictory clinical evidence, high spontaneous recovery rate, and possible placebo effects. In conclusion, there is a dearth of structured research adhering to a common protocol, which makes comparison of trials and assessment of potential treatment outcomes difficult. Further research is warranted, taking some key recommendations into consideration.

Apheresis for idiopathic sudden hearing loss: reviewing the evidence.

Plasmapheresis has been used for various conditions for a number of years. Recently, its application for idiopathic sudden hearing loss (ISHL) has met with increasing interest. ISHL affects about 10-20 per 100,000 persons per year, impairing not only their hearing but also their ability to interact socially and their quality of life. ISHL is thought to be a sequela of an underlying microvascular disorder caused by a local hyperviscosity syndrome in the cochlear vessels. Plasmapheresis can effectively lower plasma and whole blood viscosity, improve erythrocyte elasticity, and reduce aggregability. Thus, it may be effectively employed in the treatment of ISHL. This article will briefly outline the background against which apheresis procedures are used in the treatment of ISHL and review studies done to date. Furthermore, a broader basis for the use of apheretic applications in the treatment of ISHL will be suggested, correlating age-adjusted ISHL incidence and age-adjusted levels of macromolecular plasma proteins such as fibrinogen. In conclusion, plasmapheresis is a promising new treatment for ISHL but more basic data on ISHL, and on apheresis applications for ISHL, are needed to safely assess treatment outcomes and possible future applications.